See, I'm not sure current LGBT issues really map onto the Nexus very well because of the all the actual and potential biological messing around that's going on. I'm also hesitant in mapping what we think we know now 1:1 into what we'll know in the future. I'll add that just because some people have enormous trauma from body image mismatch doesn't mean that everyone necessarily would.

Gender transition comes up as soon as Mirror Dance, actually, and the poor over-boobed girl clone doomed to receive some old man's brain is far more problematic a representation in my mind than Donna...